Apparently, sometimes (rarely) a male lion and female tiger will mate in captivity. Their offspring can be really, really big.
http://www.sierrasafarizoo.com/animals/liger.htm
http://en.wikipedia.org/wiki/Liger
http://www.snopes.com/photos/animals/liger.asp
Google search
Google image search
If a male tiger mates with a female lion, the offspring is called a tigon. They might look like ligers, but aren't as big.
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